An opioid analgesic, a partial agonist at the mu (µ) opioid receptors. It provides relatively long-lasting relief of moderate pain. A controlled substance in many countries.

Drug class
Anaesthetics & Sedatives
Registered species
3
Recorded effects
16
Related products
2

Pharmacological information

A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.

Mechanism of action

An opioid analgesic, a partial agonist at the mu (µ) opioid receptors. It provides relatively long-lasting relief of moderate pain. A controlled substance in many countries.

Indications

  • Pain relief after surgery or in painful conditions
  • In combination with sedatives within anesthesia protocols

Contraindications & warnings

  • Severe respiratory insufficiency
  • Caution in hepatic impairment and head injuries

Drug interactions

  • Enhanced central and respiratory depression with sedatives and anesthetics
  • May reduce the efficacy of full opioid agonists when combined

Human-safety warning

A controlled opioid with potential for abuse; it is stored and documented under narcotics regulations, and accidental self-injection may cause respiratory depression requiring immediate medical care.

Withdrawal periods

Note: Source: UK Veterinary Medicines Directorate (VMD). The figures are a guidance reference that may differ from the product registered in your country — always verify the locally approved leaflet and consult a veterinarian before slaughter or consuming products.
Vetergesic Multidose, 0.3 mg/ml Solution for Injection for Dogs, Cats and Horses
Solution for injection · Ceva Sante Animale
SPC leaflet ↗
SpeciesMeatMilkEggs
Horses———
Buprelieve Multidose 0.3 mg/ml Solution for Injection for Dogs, Cats and Horses
Solution for injection · Zoetis UK Limited
SPC leaflet ↗
SpeciesMeatMilkEggs
Horses———

Recorded adverse effects

openFDA veterinary reports — the numbers are report counts, not a severity rate.

Cats

Behavioural disorder NOS935
Dilated pupils709
Not eating639
Hyperactivity561
Dysphoria505
Anorexia440
Death388
Lethargy (see also Central nervous system depression in 'Neurological')369

Dogs

Vomiting250
Lethargy (see also Central nervous system depression in 'Neurological')191
Diarrhoea166
Death by euthanasia154
Anorexia148
Death139
Not eating115
Other abnormal test result NOS114