Ceftiofur
AntibioticsA third-generation cephalosporin, a bactericidal beta-lactam antibiotic that binds to penicillin-binding proteins, inhibiting cell-wall construction. Broad-spectrum with relative stability against many beta-lactamase enzymes.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A third-generation cephalosporin, a bactericidal beta-lactam antibiotic that binds to penicillin-binding proteins, inhibiting cell-wall construction. Broad-spectrum with relative stability against many beta-lactamase enzymes.
Indications
- Respiratory disease in cattle and pigs caused by susceptible bacteria
- Bacterial foot rot in cattle
Contraindications & warnings
- Hypersensitivity to cephalosporins or penicillins
Drug interactions
- Theoretical antagonism with bacteriostatic antibiotics
Prudent use of antibiotics
Third- and fourth-generation cephalosporins are classified as "highest-priority critically important" by the WHO; they are reserved for cases where alternatives fail or where susceptibility testing confirms the need.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 8 days | zero | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 8 days | zero | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 8 days | zero | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 6 days | zero | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 8 days | zero | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 9 days | zero | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •World Health Organization — Critically Important Antimicrobials (WHO CIA)
- •Always verify the locally approved leaflet and consult a veterinarian.