Clenbuterol Hydrochloride
RespiratoryA bronchodilator and uterine relaxant, an agonist at beta-2 adrenergic receptors. It stimulates these receptors in bronchial smooth muscle, relaxing it and widening the airway, and it has a uterine-relaxant (tocolytic) effect. It is used particularly in horses.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A bronchodilator and uterine relaxant, an agonist at beta-2 adrenergic receptors. It stimulates these receptors in bronchial smooth muscle, relaxing it and widening the airway, and it has a uterine-relaxant (tocolytic) effect. It is used particularly in horses.
Indications
- Respiratory diseases accompanied by bronchoconstriction in horses
- Uterine relaxation in certain obstetric situations
Contraindications & warnings
- Not to be used in food-producing animals for fattening — prohibited as a growth promoter
- Heart disease and tachycardia
Drug interactions
- Its effect is antagonized by beta-adrenergic blockers
- Its cardiac effects may be aggravated with other sympathomimetic drugs
Human-safety warning
Human hazard: it is illicitly misused as a growth promoter, and its residues in meat may cause poisoning (tachycardia and tremor). The prohibition on its use in the food chain is observed.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | 28 days | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | 28 days | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | 28 days | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 14 days | 60 hours | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | 28 days | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | 28 days | — | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •Always verify the locally approved leaflet and consult a veterinarian.