Closantel
AntiparasiticsA salicylanilide antiparasitic effective against liver flukes, some blood-feeding roundworms, and external parasites. It uncouples oxidative phosphorylation in the parasite's mitochondria, depriving it of energy and killing it.
Drug class
Antiparasitics
Registered species
2
Recorded effects
0
Related products
4
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A salicylanilide antiparasitic effective against liver flukes, some blood-feeding roundworms, and external parasites. It uncouples oxidative phosphorylation in the parasite's mitochondria, depriving it of energy and killing it.
Indications
- Liver fluke disease in ruminants
- Some blood-feeding roundworms (such as Haemonchus)
Contraindications & warnings
- Overdose may cause visual disturbances and blindness — approved use limits are observed
- Adherence to milk and meat withdrawal periods
Drug interactions
- Caution when combined with other drugs that are highly plasma-protein bound
Withdrawal periods
Note: Source: UK Veterinary Medicines Directorate (VMD). The figures are a guidance reference that may differ from the product registered in your country — always verify the locally approved leaflet and consult a veterinarian before slaughter or consuming products.
Closamectin Solution for Injection for Cattle
Solution for injection · Norbrook Laboratories Limited
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 49 days | — | — |
Closamectin 5 mg/ml/125 mg/ml Solution for Injection for Sheep
Solution for injection · Norbrook Laboratories Limited
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Sheep | 28 days | — | — |
Closiver 5 mg/ml + 125 mg/ml Solution for Injection for Sheep
Solution for injection · Norbrook Laboratories Limited
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Sheep | 28 days | — | — |
Norofas Pour-on Solution for Cattle
Pour-on solution · Norbrook Laboratories Limited
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 58 days | — | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
No adverse-effect data recorded for this ingredient yet.
Related products
Closamectin Solution for Injection for Cattle
Solution for injection · Norbrook Laboratories Limited
Closamectin 5 mg/ml/125 mg/ml Solution for Injection for Sheep
Solution for injection · Norbrook Laboratories Limited
Closiver 5 mg/ml + 125 mg/ml Solution for Injection for Sheep
Solution for injection · Norbrook Laboratories Limited
Norofas Pour-on Solution for Cattle
Pour-on solution · Norbrook Laboratories Limited
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •Always verify the locally approved leaflet and consult a veterinarian.