d-Cloprostenol
Hormones & EndocrineA synthetic analogue of prostaglandin F2α, luteolytic in action. It causes regression of the corpus luteum in the ovary, lowering progesterone, which is used to control the estrus cycle and to induce parturition or therapeutic abortion.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A synthetic analogue of prostaglandin F2α, luteolytic in action. It causes regression of the corpus luteum in the ovary, lowering progesterone, which is used to control the estrus cycle and to induce parturition or therapeutic abortion.
Indications
- Control and synchronization of the estrus cycle in cattle and horses
- Treatment of ovarian cysts and chronic pyometra
- Induction of parturition or therapeutic abortion at certain stages
Contraindications & warnings
- Not given to pregnant animals unless termination of pregnancy is intended
- Caution in animals with spastic respiratory disease
Drug interactions
- Its uterine effects may be aggravated with oxytocin
Human-safety warning
Human hazard: it is absorbed through the skin; pregnant women and asthmatics must avoid handling it, and any skin contact should be washed off immediately, as it may cause miscarriage or bronchospasm.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | zero | zero | — |
| Horses | 2 days | zero | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 1 days | zero | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •Always verify the locally approved leaflet and consult a veterinarian.