Danofloxacin
AntibioticsA bactericidal fluoroquinolone antibiotic. It inhibits DNA gyrase and topoisomerase IV, the enzymes required for bacterial DNA replication. It is particularly effective against Gram-negative bacteria and Mycoplasma, and is used for respiratory disease in livestock.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A bactericidal fluoroquinolone antibiotic. It inhibits DNA gyrase and topoisomerase IV, the enzymes required for bacterial DNA replication. It is particularly effective against Gram-negative bacteria and Mycoplasma, and is used for respiratory disease in livestock.
Indications
- Respiratory disease in cattle and pigs caused by susceptible bacteria
Contraindications & warnings
- Damages growing cartilage — avoided during the growth phase
- May lower the seizure threshold — caution in nervous-system disorders
Drug interactions
- Metal cations (calcium, magnesium, iron, aluminum) reduce its absorption
- Theoretical antagonism with bacteriostatic antibiotics
Prudent use of antibiotics
Fluoroquinolones are classified as "highest-priority critically important" by the WHO; they are reserved for cases where alternatives fail or where susceptibility testing confirms the need.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 8 days | 4 days | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •World Health Organization — Critically Important Antimicrobials (WHO CIA)
- •Always verify the locally approved leaflet and consult a veterinarian.