Detomidine Hydrochloride
Anaesthetics & SedativesA sedative and analgesic, an agonist at alpha-2 adrenergic receptors that reduces noradrenaline release, producing deep sedation, analgesia, and muscle relaxation. It is used particularly in horses and cattle.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A sedative and analgesic, an agonist at alpha-2 adrenergic receptors that reduces noradrenaline release, producing deep sedation, analgesia, and muscle relaxation. It is used particularly in horses and cattle.
Indications
- Sedation and analgesia for examinations and minor procedures
- Premedication for anesthesia and in combination with other anesthetics
Contraindications & warnings
- Heart disease, bradycardia, respiratory insufficiency, and hepatic or renal impairment
- Late pregnancy — may affect the uterus
Drug interactions
- Enhanced central depression with other sedatives and anesthetics
- Its effect is reversed by alpha-2 antagonists (such as atipamezole)
Human-safety warning
Human hazard: accidental self-injection or ingestion may cause severe sedation and a fall in blood pressure and respiration. Seek medical care immediately upon any accidental exposure.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | 2 days | 12 hours | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | 2 days | 12 hours | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | 1 days | 12 hours | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •Always verify the locally approved leaflet and consult a veterinarian.