Dexamethasone
CorticosteroidsA potent, long-acting synthetic glucocorticoid. It binds to intracellular glucocorticoid receptors, regulating gene expression, thereby powerfully suppressing inflammation and the immune response and affecting the metabolism of carbohydrates, proteins, and fats.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A potent, long-acting synthetic glucocorticoid. It binds to intracellular glucocorticoid receptors, regulating gene expression, thereby powerfully suppressing inflammation and the immune response and affecting the metabolism of carbohydrates, proteins, and fats.
Indications
- Inflammatory and allergic conditions
- Some cases of shock and ketosis (at veterinary discretion)
- Induction of parturition in cattle at certain stages
Contraindications & warnings
- Uncontrolled systemic infection (it suppresses immunity)
- Diabetes mellitus, heart failure, and peptic ulcer
- Pregnancy — may induce abortion or premature birth
- Not to be stopped abruptly after prolonged use (risk of adrenal insufficiency)
Drug interactions
- Increased risk of peptic ulcer with NSAIDs
- Hypokalemia with diuretics
- May reduce the efficacy of insulin and vaccines
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 8 days | 3 days | — |
| Horses | 8 days | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 8 days | 3 days | — |
| Horses | 8 days | — | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •Always verify the locally approved leaflet and consult a veterinarian.