Dihydrostreptomycin Sulphate
AntibioticsA bactericidal aminoglycoside antibiotic that binds to the 30S ribosomal subunit, inhibiting protein synthesis. Effective against aerobic Gram-negative bacteria, and often combined with penicillin to broaden the spectrum.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A bactericidal aminoglycoside antibiotic that binds to the 30S ribosomal subunit, inhibiting protein synthesis. Effective against aerobic Gram-negative bacteria, and often combined with penicillin to broaden the spectrum.
Indications
- Infections caused by susceptible aerobic Gram-negative bacteria
- Some cases of leptospirosis
Contraindications & warnings
- Nephrotoxicity and ototoxicity (especially vestibular) — caution in renal impairment and dehydration
- May cause neuromuscular blockade
- Long tissue withdrawal periods — strongly considered in food animals
Drug interactions
- Nephrotoxicity is aggravated with loop diuretics and nephrotoxic drugs
- Enhances neuromuscular blockade with anesthetics and muscle relaxants
Prudent use of antibiotics
Prescribed based on diagnosis and susceptibility testing where possible, to limit antibiotic resistance.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 23 days | 60 hours | — |
| Sheep | 31 days | — | — |
| Horses | — | — | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •World Organisation for Animal Health (WOAH) — Prudent use of antimicrobials
- •Always verify the locally approved leaflet and consult a veterinarian.