Enrofloxacin
AntibioticsA bactericidal fluoroquinolone antibiotic. It inhibits DNA gyrase and topoisomerase IV, the enzymes required for coiling and replication of bacterial DNA, halting bacterial multiplication. It is particularly effective against Gram-negative bacteria.
Drug class
Antibiotics
Registered species
8
Recorded effects
16
Related products
12
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A bactericidal fluoroquinolone antibiotic. It inhibits DNA gyrase and topoisomerase IV, the enzymes required for coiling and replication of bacterial DNA, halting bacterial multiplication. It is particularly effective against Gram-negative bacteria.
Indications
- Respiratory, urinary, gastrointestinal, and skin infections caused by susceptible Gram-negative bacteria
Contraindications & warnings
- Damages growing cartilage — avoided during the growth phase in dogs and horses
- May lower the seizure threshold — caution in nervous-system disorders
- High doses in cats may cause retinal damage and blindness
Drug interactions
- Metal cations (calcium, magnesium, iron, aluminum) reduce its absorption
- May raise blood theophylline levels
- Theoretical antagonism with bacteriostatic antibiotics
Prudent use of antibiotics
Fluoroquinolones are classified as "highest-priority critically important" by the WHO; they are reserved for cases where alternatives fail or where susceptibility testing confirms the need.
Withdrawal periods
Note: Source: UK Veterinary Medicines Directorate (VMD). The figures are a guidance reference that may differ from the product registered in your country — always verify the locally approved leaflet and consult a veterinarian before slaughter or consuming products.
Enrox Max 100 mg/ml Solution for Injection for Cattle and Pigs
Solution for injection · KRKA, d.d., Novo mesto
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 14 days | 5 days | — |
Enroxil 100 mg/ml Solution for Injection for Cattle and Pigs
Solution for injection · KRKA, d.d., Novo mesto
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 12 days | 4 days | — |
Enroxil 50 mg/ml Solution for Injection for Calves, Pigs and Dogs
Solution for injection · KRKA, d.d., Novo mesto
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 12 days | — | — |
Enroxil 100 mg/ml Oral Solution for Chickens and Turkeys
Oral solution · KRKA, d.d., Novo mesto
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Chickens | 7 days | — | — |
| Turkeys | 13 days | — | — |
Fenoflox 50 mg/ml Solution for Injection for Cattle, Pigs, Dogs and Cats
Solution for injection · Chanelle Pharmaceuticals Manufacturing Ltd
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 12 days | — | — |
Fenoflox 100 mg/ml Solution for Injection for Cattle and Pigs
Solution for injection · Chanelle Pharmaceuticals Manufacturing Ltd
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 12 days | 4 days | — |
Valemas 50 mg/ml Solution for Injection for Cattle, Sheep, Goats, Pigs, Dogs and Cats
Solution for injection · Fatro S.p.A.
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 12 days | — | — |
| Sheep | 4 days | 3 days | — |
| Goats | 6 days | 4 days | — |
Enrotron 100 mg/ml Solution for Use in Drinking Water for Chicken, Turkeys and Rabbits
Solution for use in drinking water · aniMedica GmbH
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Chickens | 7 days | — | — |
| Turkeys | 13 days | — | — |
| Rabbits | 15 days | — | — |
Lanflox 100 mg/ml Solution for Use in Drinking Water for Chickens and Turkeys
Solution for use in drinking water · Vetpharma Animal Health, S.L
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Chickens | 7 days | — | — |
| Turkeys | 13 days | — | — |
Enrocare 25 mg/ml Concentrate for Oral Solution for Pet Rabbits, Rodents, Ornamental Birds and Reptiles
Concentrate for oral solution · Ecuphar NV
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Rabbits | — | — | — |
Enrodexil 100 mg/ml Solution for Injection for Cattle and Pigs
Solution for injection · Industrial Veterinaria, S.A.
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 5 days | 3 days | — |
| Cattle | 12 days | 4 days | — |
Orniflox 25 mg/ml Concentrate for Oral Solution for Pet Rabbits, Rodents, Ornamental Birds and Reptiles
Concentrate for oral solution · Avimedical B.V.
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Rabbits | — | — | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Dogs
Vomiting780
Lethargy (see also Central nervous system depression in 'Neurological')474
Anorexia413
Death by euthanasia382
Death333
Other abnormal test result NOS329
Diarrhoea302
Ataxia246
Cats
Mydriasis451
Blindness398
Retinal disorder NOS244
Death by euthanasia163
Anorexia148
Peripheral nervous system disorder NOS130
Vomiting120
Ataxia119
Related products
Enrox Max 100 mg/ml Solution for Injection for Cattle and Pigs
Solution for injection · KRKA, d.d., Novo mesto
Enroxil 100 mg/ml Solution for Injection for Cattle and Pigs
Solution for injection · KRKA, d.d., Novo mesto
Enroxil 50 mg/ml Solution for Injection for Calves, Pigs and Dogs
Solution for injection · KRKA, d.d., Novo mesto
Enroxil 100 mg/ml Oral Solution for Chickens and Turkeys
Oral solution · KRKA, d.d., Novo mesto
Fenoflox 50 mg/ml Solution for Injection for Cattle, Pigs, Dogs and Cats
Solution for injection · Chanelle Pharmaceuticals Manufacturing Ltd
Fenoflox 100 mg/ml Solution for Injection for Cattle and Pigs
Solution for injection · Chanelle Pharmaceuticals Manufacturing Ltd
Valemas 50 mg/ml Solution for Injection for Cattle, Sheep, Goats, Pigs, Dogs and Cats
Solution for injection · Fatro S.p.A.
Enrotron 100 mg/ml Solution for Use in Drinking Water for Chicken, Turkeys and Rabbits
Solution for use in drinking water · aniMedica GmbH
Lanflox 100 mg/ml Solution for Use in Drinking Water for Chickens and Turkeys
Solution for use in drinking water · Vetpharma Animal Health, S.L
Enrocare 25 mg/ml Concentrate for Oral Solution for Pet Rabbits, Rodents, Ornamental Birds and Reptiles
Concentrate for oral solution · Ecuphar NV
Enrodexil 100 mg/ml Solution for Injection for Cattle and Pigs
Solution for injection · Industrial Veterinaria, S.A.
Orniflox 25 mg/ml Concentrate for Oral Solution for Pet Rabbits, Rodents, Ornamental Birds and Reptiles
Concentrate for oral solution · Avimedical B.V.
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •Adverse effects: the openFDA veterinary database.
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •World Health Organization — Critically Important Antimicrobials (WHO CIA)
- •Always verify the locally approved leaflet and consult a veterinarian.