A potent non-steroidal anti-inflammatory drug (NSAID) that non-selectively inhibits cyclooxygenase (COX), reducing the prostaglandins that cause inflammation, pain, and fever, with a well-known effect against endotoxemia.

Drug class
Anti-inflammatories & Analgesics
Registered species
2
Recorded effects
0
Related products
4

Pharmacological information

A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.

Mechanism of action

A potent non-steroidal anti-inflammatory drug (NSAID) that non-selectively inhibits cyclooxygenase (COX), reducing the prostaglandins that cause inflammation, pain, and fever, with a well-known effect against endotoxemia.

Indications

  • Pain and inflammation relief in musculoskeletal disorders
  • Colic and abdominal pain in horses
  • Acute conditions accompanied by fever and endotoxemia

Contraindications & warnings

  • Gastrointestinal ulceration or bleeding, renal impairment, and dehydration
  • Intramuscular injection in cattle may carry a risk of clostridial myositis — the intravenous route is preferred, per the label
  • Not to be combined with another NSAID or a corticosteroid

Drug interactions

  • Increased risk of nephrotoxicity with diuretics, ACE inhibitors, and aminoglycosides
  • Increased risk of ulceration with corticosteroids and other anti-inflammatory drugs

Withdrawal periods

Note: Source: UK Veterinary Medicines Directorate (VMD). The figures are a guidance reference that may differ from the product registered in your country — always verify the locally approved leaflet and consult a veterinarian before slaughter or consuming products.
Hexasol LA Solution for Injection for Cattle
Solution for injection · Norbrook Laboratories Limited
SPC leaflet ↗
SpeciesMeatMilkEggs
Cattle35 days——
Resflor 300/16.5 mg/ml Solution for Injection for Cattle
Solution for injection · Intervet International B.V.
SPC leaflet ↗
SpeciesMeatMilkEggs
Cattle46 days——
Meflosyl 5% Solution for Injection
Solution for injection · Zoetis UK Limited
SPC leaflet ↗
SpeciesMeatMilkEggs
Horses———
Cyclofin 300 mg/ml + 20 mg/ml Solution for Injection for Cattle
Solution for injection · Dechra Regulatory B.V.
SPC leaflet ↗
SpeciesMeatMilkEggs
Cattle35 days——

Recorded adverse effects

openFDA veterinary reports — the numbers are report counts, not a severity rate.

No adverse-effect data recorded for this ingredient yet.