Gabapentin
Anaesthetics & SedativesAn analgesic for neuropathic pain and an anticonvulsant, structurally similar to the neurotransmitter GABA. It binds to the α2δ subunit of voltage-gated calcium channels, reducing the release of excitatory neurotransmitters, thereby relieving chronic and neuropathic pain and providing sedation.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
An analgesic for neuropathic pain and an anticonvulsant, structurally similar to the neurotransmitter GABA. It binds to the α2δ subunit of voltage-gated calcium channels, reducing the release of excitatory neurotransmitters, thereby relieving chronic and neuropathic pain and providing sedation.
Indications
- Chronic and neuropathic pain (as adjunctive treatment)
- Relief of anxiety and stress before clinic visits in cats
Contraindications & warnings
- Caution in renal impairment (it is excreted by the kidneys)
- Not to be stopped abruptly after prolonged use (risk of rebound seizures)
Drug interactions
- Enhanced sedation with other central nervous system depressants
- Antacids may reduce its absorption
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Dogs
Cats
Sources
- •Adverse effects: the openFDA veterinary database.
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •Always verify the locally approved leaflet and consult a veterinarian.