Gamithromycin
AntibioticsA long-acting macrolide antibiotic that binds to the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It concentrates in lung tissue, giving a prolonged effect, and is used particularly for bovine respiratory disease.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A long-acting macrolide antibiotic that binds to the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It concentrates in lung tissue, giving a prolonged effect, and is used particularly for bovine respiratory disease.
Indications
- Bovine respiratory disease caused by susceptible bacteria (Mannheimia, Pasteurella, and Histophilus)
Contraindications & warnings
- Hypersensitivity to macrolides
- May cause transient local swelling at the injection site
Drug interactions
- Antagonism with lincosamides and phenicols due to competition for the same binding site
Prudent use of antibiotics
Prescribed based on diagnosis and susceptibility testing where possible, to limit antibiotic resistance.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 64 days | — | — |
| Sheep | 29 days | — | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •World Organisation for Animal Health (WOAH) — Prudent use of antimicrobials
- •Always verify the locally approved leaflet and consult a veterinarian.