Marbofloxacin
AntibioticsA bactericidal fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase IV, the enzymes required for bacterial DNA replication. Particularly effective against Gram-negative bacteria.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A bactericidal fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase IV, the enzymes required for bacterial DNA replication. Particularly effective against Gram-negative bacteria.
Indications
- Respiratory, urinary, and skin infections caused by susceptible bacteria
- Bacterial mastitis in cattle
Contraindications & warnings
- Damages growing cartilage — avoided during the growth phase in dogs and horses
- May lower the seizure threshold — caution in nervous-system disorders
- Caution regarding ocular toxicity in cats at high doses
Drug interactions
- Metal cations (calcium, magnesium, iron, aluminum) reduce its absorption
- Theoretical antagonism with bacteriostatic antibiotics
Prudent use of antibiotics
Fluoroquinolones are classified as "highest-priority critically important" by the WHO; they are reserved for cases where alternatives fail or where susceptibility testing confirms the need.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 3 days | 3 days | — |
| Cattle | 6 days | 36 hours | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 6 days | 36 hours | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 6 days | 36 hours | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •World Health Organization — Critically Important Antimicrobials (WHO CIA)
- •Always verify the locally approved leaflet and consult a veterinarian.