Maropitant Citrate
GastrointestinalAn antiemetic that works by blocking neurokinin-1 (NK-1) receptors, preventing the neurotransmitter 'substance P' from binding in the brain's vomiting center, thereby stopping vomiting of both central and peripheral origin. It is used in dogs and cats.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
An antiemetic that works by blocking neurokinin-1 (NK-1) receptors, preventing the neurotransmitter 'substance P' from binding in the brain's vomiting center, thereby stopping vomiting of both central and peripheral origin. It is used in dogs and cats.
Indications
- Prevention and treatment of vomiting (including motion sickness and chemotherapy-associated vomiting)
Contraindications & warnings
- Caution in hepatic impairment (it is metabolized in the liver)
- It should not mask an obstructive cause of vomiting that requires intervention — the cause is diagnosed
Drug interactions
- Caution when combined with other drugs that are highly plasma-protein bound
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Dogs
Cats
Sources
- •Adverse effects: the openFDA veterinary database.
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •Always verify the locally approved leaflet and consult a veterinarian.