Neomycin
AntibioticsA bactericidal aminoglycoside antibiotic that binds to the 30S ribosomal subunit, causing misreading of the genetic code. It is poorly absorbed from the gut, so it is often used for local effect in the gastrointestinal tract or on the skin.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A bactericidal aminoglycoside antibiotic that binds to the 30S ribosomal subunit, causing misreading of the genetic code. It is poorly absorbed from the gut, so it is often used for local effect in the gastrointestinal tract or on the skin.
Indications
- Enteric infections caused by susceptible Gram-negative bacteria (local effect)
- Topical use on the skin, eye, and ear
Contraindications & warnings
- Nephrotoxicity and ototoxicity if absorbed systemically — systemic use is avoided
- Caution when the intestinal mucosa is damaged, where absorption increases
- Long tissue withdrawal periods — considered in food animals
Drug interactions
- Enhances neuromuscular blockade with anesthetics and muscle relaxants
- Nephrotoxicity is aggravated with other nephrotoxic drugs
Prudent use of antibiotics
Prescribed based on diagnosis and susceptibility testing where possible, to limit antibiotic resistance.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 14 days | — | — |
| Chickens | 14 days | — | zero |
| Turkeys | 14 days | — | zero |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 28 days | — | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •World Organisation for Animal Health (WOAH) — Prudent use of antimicrobials
- •Always verify the locally approved leaflet and consult a veterinarian.