Paromomycin
AntibioticsAn orally administered aminoglycoside antibiotic that is poorly absorbed from the gut, so its effect remains local within the intestinal lumen. It binds to the 30S ribosomal subunit, inhibiting bacterial protein synthesis.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
An orally administered aminoglycoside antibiotic that is poorly absorbed from the gut, so its effect remains local within the intestinal lumen. It binds to the 30S ribosomal subunit, inhibiting bacterial protein synthesis.
Indications
- Enteric infections caused by susceptible bacteria
- Some cases of cryptosporidiosis, per approved uses
Contraindications & warnings
- Caution when severe intestinal lesions are present, as they may increase systemic absorption
- Risk of nephrotoxicity and ototoxicity if absorbed systemically
Drug interactions
- Nephrotoxicity and ototoxicity are aggravated with other aminoglycosides or nephrotoxic drugs
Prudent use of antibiotics
Prescribed based on diagnosis and susceptibility testing where possible, to limit antibiotic resistance.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 62 days | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Goats | 24 days | — | — |
| Sheep | 24 days | — | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •World Organisation for Animal Health (WOAH) — Prudent use of antimicrobials
- •Always verify the locally approved leaflet and consult a veterinarian.