Phenylbutazone
Anti-inflammatories & AnalgesicsA pyrazolone non-steroidal anti-inflammatory drug (NSAID), used particularly in horses. It inhibits the cyclooxygenase (COX) enzyme, reducing prostaglandins and relieving pain and inflammation, especially in the musculoskeletal system.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A pyrazolone non-steroidal anti-inflammatory drug (NSAID), used particularly in horses. It inhibits the cyclooxygenase (COX) enzyme, reducing prostaglandins and relieving pain and inflammation, especially in the musculoskeletal system.
Indications
- Muscular, joint, and bone pain and inflammation in horses
Contraindications & warnings
- Not to be used in food-producing animals (including horses intended for slaughter) — prohibited in the food chain
- Peptic ulcer, renal or hepatic impairment, and dehydration
Drug interactions
- Not combined with other NSAIDs or corticosteroids
- Competes with drugs highly bound to plasma proteins (such as anticoagulants)
Human-safety warning
Human hazard: associated with serious blood disorders (agranulocytosis); it is prohibited from entering the human food chain, and precautions are taken when handling.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | — | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Horses | — | — | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •Always verify the locally approved leaflet and consult a veterinarian.