Selamectin
AntiparasiticsA topical (spot-on) antiparasitic of the macrocyclic lactone (avermectin) class. It binds to glutamate-gated chloride channels in parasites, paralyzing and killing them. It is used in dogs and cats against fleas, some mites, certain worms, and for heartworm prevention.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A topical (spot-on) antiparasitic of the macrocyclic lactone (avermectin) class. It binds to glutamate-gated chloride channels in parasites, paralyzing and killing them. It is used in dogs and cats against fleas, some mites, certain worms, and for heartworm prevention.
Indications
- Fleas, ear mites, and some forms of mange
- Prevention of heartworm disease
Contraindications & warnings
- Not used in animals younger than the authorized age
- Caution in sick or convalescing animals per the label
Drug interactions
- Its neurological effect may be aggravated by drugs that enhance GABA activity
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Dogs
Cats
Sources
- •Adverse effects: the openFDA veterinary database.
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •Always verify the locally approved leaflet and consult a veterinarian.