Tilmicosin
AntibioticsA macrolide antibiotic that binds to the 50S ribosomal subunit and inhibits protein synthesis. It is used particularly for respiratory disease in ruminants.
Pharmacological information
A class-level scientific overview for general reference — no doses. The ultimate reference is always the locally approved product leaflet and consultation with a veterinarian.
Mechanism of action
A macrolide antibiotic that binds to the 50S ribosomal subunit and inhibits protein synthesis. It is used particularly for respiratory disease in ruminants.
Indications
- Respiratory disease in cattle and sheep caused by susceptible bacteria (Mannheimia and Pasteurella)
Contraindications & warnings
- Not to be injected intravenously in animals — may cause cardiac death
- Not used in horses, goats, or primates, per its labels
Drug interactions
- Beta-adrenergic agonists may increase its cardiac toxicity
Prudent use of antibiotics
Prescribed based on diagnosis and susceptibility testing where possible, to limit antibiotic resistance.
Human-safety warning
Grave human hazard: accidental self-injection may be fatal (cardiac toxicity). Take utmost care when handling, and seek emergency medical help immediately, showing the label to the physician, in the event of any accidental injection.
Withdrawal periods
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 70 days | 36 days | — |
| Sheep | 42 days | 18 days | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 42 days | — | — |
| Chickens | 12 days | — | — |
| Turkeys | 19 days | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 42 days | — | — |
| Chickens | 12 days | — | — |
| Turkeys | 19 days | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 42 days | — | — |
| Chickens | 12 days | — | — |
| Turkeys | 19 days | — | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 70 days | 36 days | — |
| Sheep | 42 days | 18 days | — |
| Species | Meat | Milk | Eggs |
|---|---|---|---|
| Cattle | 70 days | 36 days | — |
| Sheep | 42 days | 18 days | — |
Recorded adverse effects
openFDA veterinary reports — the numbers are report counts, not a severity rate.
Related products
Sources
- •Withdrawal periods: UK Veterinary Medicines Directorate (VMD).
- •European Medicines Agency (EMA) — Veterinary medicines
- •Merck Veterinary Manual — Pharmacology
- •World Organisation for Animal Health (WOAH) — Prudent use of antimicrobials
- •Always verify the locally approved leaflet and consult a veterinarian.