Dogs

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Active ingredients with withdrawal periods for this species

Tap any ingredient to view detailed withdrawal periods by product (meat, milk, and eggs).

No withdrawal periods recorded for this species yet.

Recorded adverse effects for this species

Real data from openFDA veterinary reports. The numbers represent the report count, not a severity rate.

Active ingredient	Symptom	Report count
Spinosad	Emesis	55,127
Spinosad	Vomiting	45,209
Milbemycin Oxime	Emesis	42,434
Milbemycin Oxime	Vomiting	37,283
Ivermectin	Lack of efficacy (endoparasite) - heartworm	22,576
Spinosad	Lethargy (see also Central nervous system depression in 'Neurological')	22,091
Milbemycin Oxime	Lethargy (see also Central nervous system depression in 'Neurological')	21,048
Spinosad	Lack of efficacy (ectoparasite) - flea	19,148
Pyrantel As Pamoate Salt	Lack of efficacy (endoparasite) - heartworm	18,299
Ivermectin, Pyrantel	INEFFECTIVE, HEARTWORM LARVAE	16,964
Ivermectin	Lack of efficacy (endoparasite) - hookworm	14,590
Ivermectin	INEFFECTIVE, HEARTWORM LARVAE	13,844
Pyrantel As Pamoate Salt	Lack of efficacy (endoparasite) - hookworm	13,737
Milbemycin Oxime	Lack of efficacy (endoparasite) - heartworm	13,241
Ivermectin	Vomiting	13,171
Afoxolaner	Vomiting	13,008
Spinosad	Lack of efficacy - NOS	12,788
Milbemycin Oxime	Lack of efficacy - NOS	12,530
Carprofen	Vomiting	12,300
Fluralaner Chew Tablets	Vomiting	11,859
Moxidectin	Vomiting	11,618
Pyrantel As Pamoate Salt	INEFFECTIVE, HEARTWORM LARVAE	11,536
Ivermectin	Digestive tract disorder NOS	10,914
Pyrantel As Pamoate Salt	Digestive tract disorder NOS	10,840
Milbemycin	INEFFECTIVE, HEARTWORM LARVAE	10,178
Milbemycin Oxime	Diarrhoea	9,874
Pyrantel As Pamoate Salt	Vomiting	9,740
Praziquantel	Vomiting	9,675
Carprofen	Anorexia	9,563
Moxidectin	Lack of efficacy (endoparasite) - heartworm	9,096
Carprofen	Elevated alanine aminotransferase (ALT)	8,530
Spinosad	Diarrhoea	8,366
Fluralaner 13.64% 12-Week Chew	Lack of efficacy (ectoparasite) - flea	8,271
Praziquantel	Lack of efficacy (endoparasite) - heartworm	8,147
Selamectin	INEFFECTIVE, HEARTWORM LARVAE	7,937
Milbemycin Oxime	INEFFECTIVE, HEARTWORM LARVAE	7,707
Carprofen	Elevated serum alkaline phosphatase (SAP)	7,572
Milbemycin Oxime	Lack of efficacy (ectoparasite) - flea	7,191
Ivermectin, Pyrantel	Lack of efficacy (endoparasite) - hookworm	6,945
Ivermectin	INEFFECTIVE, HOOKS	6,884
Ivermectin	Cardiac disorder NOS	6,612
Pyrantel As Pamoate Salt	Cardiac disorder NOS	6,512
Pyrantel As Pamoate Salt	INEFFECTIVE, HOOKS	6,441
Fluralaner 13.64% 12-Week Chew	Vomiting	6,349
Carprofen	Depression	5,982
Ivermectin	Lack of efficacy - NOS	5,815
Pyrantel As Pamoate Salt	Lack of efficacy - NOS	5,301
Spinosad	INEFFECTIVE, HEARTWORM LARVAE	5,297
Spinosad	Seizure NOS	5,263
Afoxolaner	Lethargy (see also Central nervous system depression in 'Neurological')	5,157
Moxidectin	Lethargy (see also Central nervous system depression in 'Neurological')	5,086
Carprofen	Diarrhoea	5,077
Moxidectin	Anaphylaxis	4,929
Nitenpyram	Lack of efficacy (ectoparasite) - flea	4,757
Afoxolaner	Diarrhoea	4,740
Afoxolaner	Lack of efficacy (ectoparasite) - tick NOS	4,661
Moxidectin	Lack of efficacy (endoparasite) - hookworm	4,509
Ivermectin, Pyrantel	INEFFECTIVE, ASCARIDS NOS	4,438
Carprofen	Elevated total bilirubin	4,404
Carprofen	Death by euthanasia	4,280
Moxidectin	Diarrhoea	4,207
Cyclosporine	Vomiting	4,148
Afoxolaner	Lack of efficacy (ectoparasite) - flea	4,102
Pyrantel Pamoate	Vomiting	4,003
Fluralaner Chew Tablets	Lack of efficacy (ectoparasite) - flea	3,989
Afoxolaner	Seizure NOS	3,849
Sarolaner	Vomiting	3,753
Moxidectin	Facial swelling (see also 'Skin')	3,711
Oclacitinib Maleate	Lack of efficacy - NOS	3,576
Praziquantel	Diarrhoea	3,455
Deracoxib	Vomiting	3,377
Fluralaner Chew Tablets	Lethargy (see also Central nervous system depression in 'Neurological')	3,285
Selamectin	Lack of efficacy (ectoparasite) - flea	3,272
Oclacitinib Maleate	Vomiting	3,211
Fluralaner Chew Tablets	Emesis (multiple)	3,084
Afoxolaner	Lack of efficacy (bacteria) - Borrelia	3,057
Praziquantel	INEFFECTIVE, HOOKS	2,951
Fluralaner 13.64% 12-Week Chew	Lack of efficacy (ectoparasite) - tick NOS	2,936
Maropitant Citrate	Vomiting	2,904
Ivermectin, Pyrantel	Vomiting	2,900
Moxidectin	INEFFECTIVE, HEARTWORM LARVAE	2,893
Selamectin	Vomiting	2,892
Milbemycin, Lufenuron	INEFFECTIVE, HEARTWORM LARVAE	2,792
Sarolaner	Seizure NOS	2,754
Oclacitinib Maleate	INEFFECTIVE, ATOPY CONTROL	2,677
Praziquantel	Lethargy (see also Central nervous system depression in 'Neurological')	2,654
Lotilaner	Vomiting	2,649
Milbemycin	Vomiting	2,630
Melarsomine Dihydrochloride	INEFFECTIVE, HEARTWORM ADULTS	2,622
Afoxolaner	Lack of efficacy (bacteria) - NOS	2,597
Fluralaner Chew Tablets	Diarrhoea	2,557
Imidacloprid	Lack of efficacy (ectoparasite) - flea	2,496
Praziquantel	Lack of efficacy (endoparasite) - hookworm	2,491
Deracoxib	Anorexia	2,420
Bedinvetmab	Death by euthanasia	2,370
Melarsomine Dihydrochloride	Lack of efficacy (endoparasite) - heartworm	2,346
Bedinvetmab	Lethargy (see also Central nervous system depression in Neurological)	2,226
Oclacitinib Maleate	Diarrhoea	2,177
Oclacitinib Maleate	Lethargy (see also Central nervous system depression in 'Neurological')	2,085
Meloxicam	Vomiting	2,048
Firocoxib	Vomiting	2,045
Pyrantel	Lack of efficacy (endoparasite) - heartworm	2,035
Fluralaner 13.64% 12-Week Chew	Emesis (multiple)	2,006
Milbemycin	Diarrhoea	2,003
Melarsomine Dihydrochloride	Vomiting	1,992
Trilostane	Vomiting	1,992
Cyclosporine	Diarrhoea	1,978
Trilostane	Lethargy (see also Central nervous system depression in 'Neurological')	1,973
Milbemycin	Lack of efficacy (endoparasite) - hookworm	1,904
Selamectin	Depression	1,876
Milbemycin	INEFFECTIVE, ASCARIDS NOS	1,862
Milbemycin	Depression	1,850
Deracoxib	Depression	1,848
Oclacitinib Maleate	INEFFECTIVE, LOSS OF EFFECT	1,797
Imidacloprid	Pruritus	1,752
Trilostane	Hyperkalaemia	1,741
Melarsomine Dihydrochloride	Injection site swelling	1,732
Selamectin	Diarrhoea	1,730
Praziquantel	Other abnormal test result NOS	1,713
Trilostane	Elevated serum alkaline phosphatase (SAP)	1,687
Deracoxib	Elevated blood urea nitrogen (BUN)	1,672
Selamectin	Lack of efficacy (endoparasite) - hookworm	1,628
Milbemycin	Lack of efficacy (endoparasite) - whipworm	1,627
Maropitant Citrate	Lethargy (see also Central nervous system depression in 'Neurological')	1,622
Bedinvetmab	Polydipsia	1,618
Ivermectin, Pyrantel	Diarrhoea	1,616
Deracoxib	Elevated serum alkaline phosphatase (SAP)	1,610
Bedinvetmab	Ataxia	1,585
Sarolaner	Lethargy (see also Central nervous system depression in 'Neurological')	1,567
Imidacloprid	Lethargy (see also Central nervous system depression in 'Neurological')	1,556
Fluralaner Chew Tablets	Lack of efficacy (ectoparasite) - tick NOS	1,547
Bedinvetmab	Seizure NOS	1,531
Bedinvetmab	Vomiting	1,529
Bedinvetmab	Polyuria	1,515
Selamectin	Anorexia	1,483
Ivermectin, Pyrantel	Depression	1,482
Trilostane	Weight loss	1,478
Deracoxib	Diarrhoea	1,477
Bedinvetmab	Diarrhoea	1,453
Deracoxib	Accidental exposure	1,440
Fluralaner Chew Tablets	Lack of efficacy (flea)	1,440
Pyrantel	Vomiting	1,431
Trilostane	Underdose	1,430
Selamectin	Pruritus	1,427
Grapiprant	Vomiting	1,424
Trilostane	Diarrhoea	1,422
Deracoxib	Elevated creatinine	1,416
Maropitant Citrate	Diarrhoea	1,408
Fluralaner Chew Tablets	Seizure NOS	1,408
Pyrantel Pamoate	Diarrhoea	1,395
Lufenuron	INEFFECTIVE, HOOKS	1,387
Trilostane	Elevated alanine aminotransferase (ALT)	1,372
Oclacitinib Maleate	Other abnormal test result NOS	1,367
Lufenuron	Vomiting	1,362
Milbemycin, Lufenuron	Vomiting	1,357
Fluralaner 13.64% 12-Week Chew	Seizure NOS	1,344
Gabapentin	Vomiting	1,344
Sarolaner	Tremor	1,337
Praziquantel	Lack of efficacy (endoparasite) - roundworm NOS	1,331
Sarolaner	Diarrhoea	1,321
Nitenpyram	Lack of efficacy (flea)	1,307
Prednisone	Vomiting	1,282
Fluralaner 13.64% 12-Week Chew	Diarrhoea	1,277
Cyclosporine	Depression	1,274
Grapiprant	Diarrhoea	1,255
Meloxicam	Anorexia	1,246
Maropitant Citrate	Anorexia	1,241
Sarolaner	Lack of efficacy (ectoparasite) - tick NOS	1,208
Firocoxib	Anorexia	1,185
Imidacloprid	Vomiting	1,174
Lufenuron	INEFFECTIVE, HEARTWORM LARVAE	1,167
Lotilaner	Diarrhoea	1,126
Oclacitinib Maleate	Elevated alanine aminotransferase (ALT)	1,101
Pyrantel Pamoate	Lethargy (see also Central nervous system depression in 'Neurological')	1,093
Fluralaner 13.64% 12-Week Chew	Lethargy (see also Central nervous system depression in 'Neurological')	1,081
Prednisone	Lethargy (see also Central nervous system depression in 'Neurological')	1,065
Melarsomine Dihydrochloride	Anorexia	1,060
Melarsomine Dihydrochloride	Injection site pain	1,058
Imidacloprid	Behavioural disorder NOS	1,057
Sarolaner	Lack of efficacy (ectoparasite) - flea	1,051
Maropitant Citrate	Death by euthanasia	1,038
Meloxicam	Diarrhoea	1,035
Maropitant Citrate	Lack of efficacy - NOS	1,026
Cyclosporine	Anorexia	1,026
Lufenuron	Diarrhoea	1,025
Melarsomine Dihydrochloride	Depression	1,024
Gabapentin	Diarrhoea	1,009
Sarolaner	Ataxia	1,004
Cyclosporine	Pruritus	988
Gabapentin	Death by euthanasia	974
Imidacloprid	Diarrhoea	969
Milbemycin	Anorexia	969
Grapiprant	Lack of efficacy - NOS	958
Fluralaner 13.64% 12-Week Chew	Lack of efficacy (bacteria) - Borrelia	954
Nitenpyram	Vomiting	950
Prednisone	Diarrhoea	948
Maropitant Citrate	Death	943
Pyrantel	INEFFECTIVE, HEARTWORM LARVAE	934
Maropitant Citrate	Elevated alanine aminotransferase (ALT)	928
Melarsomine Dihydrochloride	Pain NOS	902
Firocoxib	Elevated blood urea nitrogen (BUN)	865
Gabapentin	Lethargy (see also Central nervous system depression in Neurological)	856
Ivermectin, Pyrantel	Anorexia	841
Imidacloprid	Other abnormal test result NOS	837
Milbemycin, Lufenuron	Depression	837
Lufenuron	Lack of efficacy (endoparasite) - heartworm	808
Lufenuron	Lethargy (see also Central nervous system depression in 'Neurological')	807
Firocoxib	Diarrhoea	799
Lufenuron	Lack of efficacy - NOS	788
Pyrantel	Lack of efficacy (endoparasite) - hookworm	784
Pyrantel Pamoate	Emesis	783
Enrofloxacin	Vomiting	780
Meloxicam	Depression	766
Prednisone	Lack of efficacy - NOS	755
Lotilaner	Lack of efficacy (ectoparasite) - tick NOS	733
Milbemycin, Lufenuron	Diarrhoea	726
Pyrantel Pamoate	Emesis (multiple)	723
Lotilaner	Other abnormal test result NOS	714
Nitenpyram	Lethargy (see also Central nervous system depression in 'Neurological')	707
Gabapentin	Not eating	688
Gabapentin	Lack of efficacy - NOS	681
Meloxicam	Elevated blood urea nitrogen (BUN)	680
Firocoxib	Depression	678
Ivermectin, Pyrantel	Convulsion	666
Nitenpyram	Lack of efficacy - NOS	666
Grapiprant	Lethargy (see also Central nervous system depression in 'Neurological')	659
Prednisone	Death by euthanasia	656
Firocoxib	Elevated serum alkaline phosphatase (SAP)	655
Pyrantel Pamoate	Anorexia	654
Firocoxib	Death	651
Lotilaner	Lack of efficacy (bacteria) - Borrelia	647
Pyrantel Pamoate	Lack of efficacy (endoparasite) - heartworm	642
Pyrantel Pamoate	Death	640
Firocoxib	Elevated creatinine	637
Pyrantel	Diarrhoea	633
Imidacloprid	Anorexia	629
Lotilaner	Lethargy (see also Central nervous system depression in 'Neurological')	624
Lotilaner	Seizure NOS	619
Milbemycin, Lufenuron	Lack of efficacy (endoparasite) - hookworm	616
Prednisone	Other abnormal test result NOS	613
Meloxicam	Death	607
Meloxicam	Lethargy (see also Central nervous system depression in 'Neurological')	606
Gabapentin	Elevated alanine aminotransferase (ALT)	593
Cefovecin	Lethargy (see also Central nervous system depression in 'Neurological')	590
Cyclosporine	Elevated serum alkaline phosphatase (SAP)	590
Meloxicam	Death by euthanasia	588
Lufenuron	Emesis	578
Milbemycin, Lufenuron	INEFFECTIVE, ASCARIDS NOS	562
Gabapentin	Decreased appetite	560
Cefovecin	Vomiting	547
Nitenpyram	Diarrhoea	541
Prednisone	Emesis	529
Prednisone	Weight loss	520
Grapiprant	Elevated alanine aminotransferase (ALT)	506
Pyrantel	Lethargy (see also Central nervous system depression in 'Neurological')	492
Fluralaner Spot-On Solution	Lack of efficacy (ectoparasite) - flea	486
Nitenpyram	Pruritus	486
Cyclosporine	Elevated alanine aminotransferase (ALT)	479
Grapiprant	Death by euthanasia	476
Enrofloxacin	Lethargy (see also Central nervous system depression in 'Neurological')	474
Milbemycin, Lufenuron	Pruritus	473
Lotilaner	Lack of efficacy (endoparasite) - heartworm	470
Grapiprant	Not eating	465
Cyclosporine	INEFFECTIVE, ATOPY CONTROL	464
Milbemycin, Lufenuron	Anorexia	451
Nitenpyram	Scratching	449
Grapiprant	Decreased appetite	427
Enrofloxacin	Anorexia	413
Pyrantel	Emesis (multiple)	408
Pyrantel	INEFFECTIVE, HOOKS	392
Enrofloxacin	Death by euthanasia	382
Cefovecin	Anorexia	340
Enrofloxacin	Death	333
Cefovecin	Death	330
Enrofloxacin	Other abnormal test result NOS	329
Enrofloxacin	Diarrhoea	302
Buprenorphine	Vomiting	250
Enrofloxacin	Ataxia	246
Cefovecin	Diarrhoea	242
Cefovecin	Death by euthanasia	218
Cefovecin	Seizure NOS	197
Cefovecin	Other abnormal test result NOS	196
Buprenorphine	Lethargy (see also Central nervous system depression in 'Neurological')	191
Buprenorphine	Diarrhoea	166
Buprenorphine	Death by euthanasia	154
Buprenorphine	Anorexia	148
Buprenorphine	Death	139
Buprenorphine	Not eating	115
Fluralaner Spot-On Solution	Lack of efficacy (ectoparasite) - tick NOS	114
Buprenorphine	Other abnormal test result NOS	114
Fluralaner Spot-On Solution	Emesis (multiple)	67
Fluralaner Spot-On Solution	Lethargy (see also Central nervous system depression in 'Neurological')	65
Fluralaner Spot-On Solution	Seizure NOS	60
Fluralaner Spot-On Solution	Vomiting	43
Fluralaner Spot-On Solution	Diarrhoea	41
Fluralaner Spot-On Solution	Drug administered at inappropriate site	33
Frunevetmab	General illness	2
Frunevetmab	Lethargy (see also Central nervous system depression in Neurological)	2
Frunevetmab	Prescribing error	2
Frunevetmab	Confusion	1
Frunevetmab	Anorexia	1
Frunevetmab	Behavioural disorder NOS	1
Frunevetmab	Emesis	1
Frunevetmab	Death by euthanasia	1