Dogs
Active ingredients with withdrawal periods for this species
Tap any ingredient to view detailed withdrawal periods by product (meat, milk, and eggs).
No withdrawal periods recorded for this species yet.
Recorded adverse effects for this species
Real data from openFDA veterinary reports. The numbers represent the report count, not a severity rate.
| Active ingredient | Symptom | Report count |
|---|---|---|
| Spinosad | Emesis | 55,127 |
| Spinosad | Vomiting | 45,209 |
| Milbemycin Oxime | Emesis | 42,434 |
| Milbemycin Oxime | Vomiting | 37,283 |
| Ivermectin | Lack of efficacy (endoparasite) - heartworm | 22,576 |
| Spinosad | Lethargy (see also Central nervous system depression in 'Neurological') | 22,091 |
| Milbemycin Oxime | Lethargy (see also Central nervous system depression in 'Neurological') | 21,048 |
| Spinosad | Lack of efficacy (ectoparasite) - flea | 19,148 |
| Pyrantel As Pamoate Salt | Lack of efficacy (endoparasite) - heartworm | 18,299 |
| Ivermectin, Pyrantel | INEFFECTIVE, HEARTWORM LARVAE | 16,964 |
| Ivermectin | Lack of efficacy (endoparasite) - hookworm | 14,590 |
| Ivermectin | INEFFECTIVE, HEARTWORM LARVAE | 13,844 |
| Pyrantel As Pamoate Salt | Lack of efficacy (endoparasite) - hookworm | 13,737 |
| Milbemycin Oxime | Lack of efficacy (endoparasite) - heartworm | 13,241 |
| Ivermectin | Vomiting | 13,171 |
| Afoxolaner | Vomiting | 13,008 |
| Spinosad | Lack of efficacy - NOS | 12,788 |
| Milbemycin Oxime | Lack of efficacy - NOS | 12,530 |
| Carprofen | Vomiting | 12,300 |
| Fluralaner Chew Tablets | Vomiting | 11,859 |
| Moxidectin | Vomiting | 11,618 |
| Pyrantel As Pamoate Salt | INEFFECTIVE, HEARTWORM LARVAE | 11,536 |
| Ivermectin | Digestive tract disorder NOS | 10,914 |
| Pyrantel As Pamoate Salt | Digestive tract disorder NOS | 10,840 |
| Milbemycin | INEFFECTIVE, HEARTWORM LARVAE | 10,178 |
| Milbemycin Oxime | Diarrhoea | 9,874 |
| Pyrantel As Pamoate Salt | Vomiting | 9,740 |
| Praziquantel | Vomiting | 9,675 |
| Carprofen | Anorexia | 9,563 |
| Moxidectin | Lack of efficacy (endoparasite) - heartworm | 9,096 |
| Carprofen | Elevated alanine aminotransferase (ALT) | 8,530 |
| Spinosad | Diarrhoea | 8,366 |
| Fluralaner 13.64% 12-Week Chew | Lack of efficacy (ectoparasite) - flea | 8,271 |
| Praziquantel | Lack of efficacy (endoparasite) - heartworm | 8,147 |
| Selamectin | INEFFECTIVE, HEARTWORM LARVAE | 7,937 |
| Milbemycin Oxime | INEFFECTIVE, HEARTWORM LARVAE | 7,707 |
| Carprofen | Elevated serum alkaline phosphatase (SAP) | 7,572 |
| Milbemycin Oxime | Lack of efficacy (ectoparasite) - flea | 7,191 |
| Ivermectin, Pyrantel | Lack of efficacy (endoparasite) - hookworm | 6,945 |
| Ivermectin | INEFFECTIVE, HOOKS | 6,884 |
| Ivermectin | Cardiac disorder NOS | 6,612 |
| Pyrantel As Pamoate Salt | Cardiac disorder NOS | 6,512 |
| Pyrantel As Pamoate Salt | INEFFECTIVE, HOOKS | 6,441 |
| Fluralaner 13.64% 12-Week Chew | Vomiting | 6,349 |
| Carprofen | Depression | 5,982 |
| Ivermectin | Lack of efficacy - NOS | 5,815 |
| Pyrantel As Pamoate Salt | Lack of efficacy - NOS | 5,301 |
| Spinosad | INEFFECTIVE, HEARTWORM LARVAE | 5,297 |
| Spinosad | Seizure NOS | 5,263 |
| Afoxolaner | Lethargy (see also Central nervous system depression in 'Neurological') | 5,157 |
| Moxidectin | Lethargy (see also Central nervous system depression in 'Neurological') | 5,086 |
| Carprofen | Diarrhoea | 5,077 |
| Moxidectin | Anaphylaxis | 4,929 |
| Nitenpyram | Lack of efficacy (ectoparasite) - flea | 4,757 |
| Afoxolaner | Diarrhoea | 4,740 |
| Afoxolaner | Lack of efficacy (ectoparasite) - tick NOS | 4,661 |
| Moxidectin | Lack of efficacy (endoparasite) - hookworm | 4,509 |
| Ivermectin, Pyrantel | INEFFECTIVE, ASCARIDS NOS | 4,438 |
| Carprofen | Elevated total bilirubin | 4,404 |
| Carprofen | Death by euthanasia | 4,280 |
| Moxidectin | Diarrhoea | 4,207 |
| Cyclosporine | Vomiting | 4,148 |
| Afoxolaner | Lack of efficacy (ectoparasite) - flea | 4,102 |
| Pyrantel Pamoate | Vomiting | 4,003 |
| Fluralaner Chew Tablets | Lack of efficacy (ectoparasite) - flea | 3,989 |
| Afoxolaner | Seizure NOS | 3,849 |
| Sarolaner | Vomiting | 3,753 |
| Moxidectin | Facial swelling (see also 'Skin') | 3,711 |
| Oclacitinib Maleate | Lack of efficacy - NOS | 3,576 |
| Praziquantel | Diarrhoea | 3,455 |
| Deracoxib | Vomiting | 3,377 |
| Fluralaner Chew Tablets | Lethargy (see also Central nervous system depression in 'Neurological') | 3,285 |
| Selamectin | Lack of efficacy (ectoparasite) - flea | 3,272 |
| Oclacitinib Maleate | Vomiting | 3,211 |
| Fluralaner Chew Tablets | Emesis (multiple) | 3,084 |
| Afoxolaner | Lack of efficacy (bacteria) - Borrelia | 3,057 |
| Praziquantel | INEFFECTIVE, HOOKS | 2,951 |
| Fluralaner 13.64% 12-Week Chew | Lack of efficacy (ectoparasite) - tick NOS | 2,936 |
| Maropitant Citrate | Vomiting | 2,904 |
| Ivermectin, Pyrantel | Vomiting | 2,900 |
| Moxidectin | INEFFECTIVE, HEARTWORM LARVAE | 2,893 |
| Selamectin | Vomiting | 2,892 |
| Milbemycin, Lufenuron | INEFFECTIVE, HEARTWORM LARVAE | 2,792 |
| Sarolaner | Seizure NOS | 2,754 |
| Oclacitinib Maleate | INEFFECTIVE, ATOPY CONTROL | 2,677 |
| Praziquantel | Lethargy (see also Central nervous system depression in 'Neurological') | 2,654 |
| Lotilaner | Vomiting | 2,649 |
| Milbemycin | Vomiting | 2,630 |
| Melarsomine Dihydrochloride | INEFFECTIVE, HEARTWORM ADULTS | 2,622 |
| Afoxolaner | Lack of efficacy (bacteria) - NOS | 2,597 |
| Fluralaner Chew Tablets | Diarrhoea | 2,557 |
| Imidacloprid | Lack of efficacy (ectoparasite) - flea | 2,496 |
| Praziquantel | Lack of efficacy (endoparasite) - hookworm | 2,491 |
| Deracoxib | Anorexia | 2,420 |
| Bedinvetmab | Death by euthanasia | 2,370 |
| Melarsomine Dihydrochloride | Lack of efficacy (endoparasite) - heartworm | 2,346 |
| Bedinvetmab | Lethargy (see also Central nervous system depression in Neurological) | 2,226 |
| Oclacitinib Maleate | Diarrhoea | 2,177 |
| Oclacitinib Maleate | Lethargy (see also Central nervous system depression in 'Neurological') | 2,085 |
| Meloxicam | Vomiting | 2,048 |
| Firocoxib | Vomiting | 2,045 |
| Pyrantel | Lack of efficacy (endoparasite) - heartworm | 2,035 |
| Fluralaner 13.64% 12-Week Chew | Emesis (multiple) | 2,006 |
| Milbemycin | Diarrhoea | 2,003 |
| Trilostane | Vomiting | 1,992 |
| Melarsomine Dihydrochloride | Vomiting | 1,992 |
| Cyclosporine | Diarrhoea | 1,978 |
| Trilostane | Lethargy (see also Central nervous system depression in 'Neurological') | 1,973 |
| Milbemycin | Lack of efficacy (endoparasite) - hookworm | 1,904 |
| Selamectin | Depression | 1,876 |
| Milbemycin | INEFFECTIVE, ASCARIDS NOS | 1,862 |
| Milbemycin | Depression | 1,850 |
| Deracoxib | Depression | 1,848 |
| Oclacitinib Maleate | INEFFECTIVE, LOSS OF EFFECT | 1,797 |
| Imidacloprid | Pruritus | 1,752 |
| Trilostane | Hyperkalaemia | 1,741 |
| Melarsomine Dihydrochloride | Injection site swelling | 1,732 |
| Selamectin | Diarrhoea | 1,730 |
| Praziquantel | Other abnormal test result NOS | 1,713 |
| Trilostane | Elevated serum alkaline phosphatase (SAP) | 1,687 |
| Deracoxib | Elevated blood urea nitrogen (BUN) | 1,672 |
| Selamectin | Lack of efficacy (endoparasite) - hookworm | 1,628 |
| Milbemycin | Lack of efficacy (endoparasite) - whipworm | 1,627 |
| Maropitant Citrate | Lethargy (see also Central nervous system depression in 'Neurological') | 1,622 |
| Bedinvetmab | Polydipsia | 1,618 |
| Ivermectin, Pyrantel | Diarrhoea | 1,616 |
| Deracoxib | Elevated serum alkaline phosphatase (SAP) | 1,610 |
| Bedinvetmab | Ataxia | 1,585 |
| Sarolaner | Lethargy (see also Central nervous system depression in 'Neurological') | 1,567 |
| Imidacloprid | Lethargy (see also Central nervous system depression in 'Neurological') | 1,556 |
| Fluralaner Chew Tablets | Lack of efficacy (ectoparasite) - tick NOS | 1,547 |
| Bedinvetmab | Seizure NOS | 1,531 |
| Bedinvetmab | Vomiting | 1,529 |
| Bedinvetmab | Polyuria | 1,515 |
| Selamectin | Anorexia | 1,483 |
| Ivermectin, Pyrantel | Depression | 1,482 |
| Trilostane | Weight loss | 1,478 |
| Deracoxib | Diarrhoea | 1,477 |
| Bedinvetmab | Diarrhoea | 1,453 |
| Deracoxib | Accidental exposure | 1,440 |
| Fluralaner Chew Tablets | Lack of efficacy (flea) | 1,440 |
| Pyrantel | Vomiting | 1,431 |
| Trilostane | Underdose | 1,430 |
| Selamectin | Pruritus | 1,427 |
| Grapiprant | Vomiting | 1,424 |
| Trilostane | Diarrhoea | 1,422 |
| Deracoxib | Elevated creatinine | 1,416 |
| Fluralaner Chew Tablets | Seizure NOS | 1,408 |
| Maropitant Citrate | Diarrhoea | 1,408 |
| Pyrantel Pamoate | Diarrhoea | 1,395 |
| Lufenuron | INEFFECTIVE, HOOKS | 1,387 |
| Trilostane | Elevated alanine aminotransferase (ALT) | 1,372 |
| Oclacitinib Maleate | Other abnormal test result NOS | 1,367 |
| Lufenuron | Vomiting | 1,362 |
| Milbemycin, Lufenuron | Vomiting | 1,357 |
| Fluralaner 13.64% 12-Week Chew | Seizure NOS | 1,344 |
| Gabapentin | Vomiting | 1,344 |
| Sarolaner | Tremor | 1,337 |
| Praziquantel | Lack of efficacy (endoparasite) - roundworm NOS | 1,331 |
| Sarolaner | Diarrhoea | 1,321 |
| Nitenpyram | Lack of efficacy (flea) | 1,307 |
| Prednisone | Vomiting | 1,282 |
| Fluralaner 13.64% 12-Week Chew | Diarrhoea | 1,277 |
| Cyclosporine | Depression | 1,274 |
| Grapiprant | Diarrhoea | 1,255 |
| Meloxicam | Anorexia | 1,246 |
| Maropitant Citrate | Anorexia | 1,241 |
| Sarolaner | Lack of efficacy (ectoparasite) - tick NOS | 1,208 |
| Firocoxib | Anorexia | 1,185 |
| Imidacloprid | Vomiting | 1,174 |
| Lufenuron | INEFFECTIVE, HEARTWORM LARVAE | 1,167 |
| Lotilaner | Diarrhoea | 1,126 |
| Oclacitinib Maleate | Elevated alanine aminotransferase (ALT) | 1,101 |
| Pyrantel Pamoate | Lethargy (see also Central nervous system depression in 'Neurological') | 1,093 |
| Fluralaner 13.64% 12-Week Chew | Lethargy (see also Central nervous system depression in 'Neurological') | 1,081 |
| Prednisone | Lethargy (see also Central nervous system depression in 'Neurological') | 1,065 |
| Melarsomine Dihydrochloride | Anorexia | 1,060 |
| Melarsomine Dihydrochloride | Injection site pain | 1,058 |
| Imidacloprid | Behavioural disorder NOS | 1,057 |
| Sarolaner | Lack of efficacy (ectoparasite) - flea | 1,051 |
| Maropitant Citrate | Death by euthanasia | 1,038 |
| Meloxicam | Diarrhoea | 1,035 |
| Cyclosporine | Anorexia | 1,026 |
| Maropitant Citrate | Lack of efficacy - NOS | 1,026 |
| Lufenuron | Diarrhoea | 1,025 |
| Melarsomine Dihydrochloride | Depression | 1,024 |
| Gabapentin | Diarrhoea | 1,009 |
| Sarolaner | Ataxia | 1,004 |
| Cyclosporine | Pruritus | 988 |
| Gabapentin | Death by euthanasia | 974 |
| Imidacloprid | Diarrhoea | 969 |
| Milbemycin | Anorexia | 969 |
| Grapiprant | Lack of efficacy - NOS | 958 |
| Fluralaner 13.64% 12-Week Chew | Lack of efficacy (bacteria) - Borrelia | 954 |
| Nitenpyram | Vomiting | 950 |
| Prednisone | Diarrhoea | 948 |
| Maropitant Citrate | Death | 943 |
| Pyrantel | INEFFECTIVE, HEARTWORM LARVAE | 934 |
| Maropitant Citrate | Elevated alanine aminotransferase (ALT) | 928 |
| Melarsomine Dihydrochloride | Pain NOS | 902 |
| Firocoxib | Elevated blood urea nitrogen (BUN) | 865 |
| Gabapentin | Lethargy (see also Central nervous system depression in Neurological) | 856 |
| Ivermectin, Pyrantel | Anorexia | 841 |
| Imidacloprid | Other abnormal test result NOS | 837 |
| Milbemycin, Lufenuron | Depression | 837 |
| Lufenuron | Lack of efficacy (endoparasite) - heartworm | 808 |
| Lufenuron | Lethargy (see also Central nervous system depression in 'Neurological') | 807 |
| Firocoxib | Diarrhoea | 799 |
| Lufenuron | Lack of efficacy - NOS | 788 |
| Pyrantel | Lack of efficacy (endoparasite) - hookworm | 784 |
| Pyrantel Pamoate | Emesis | 783 |
| Enrofloxacin | Vomiting | 780 |
| Meloxicam | Depression | 766 |
| Prednisone | Lack of efficacy - NOS | 755 |
| Lotilaner | Lack of efficacy (ectoparasite) - tick NOS | 733 |
| Milbemycin, Lufenuron | Diarrhoea | 726 |
| Pyrantel Pamoate | Emesis (multiple) | 723 |
| Lotilaner | Other abnormal test result NOS | 714 |
| Nitenpyram | Lethargy (see also Central nervous system depression in 'Neurological') | 707 |
| Gabapentin | Not eating | 688 |
| Gabapentin | Lack of efficacy - NOS | 681 |
| Meloxicam | Elevated blood urea nitrogen (BUN) | 680 |
| Firocoxib | Depression | 678 |
| Nitenpyram | Lack of efficacy - NOS | 666 |
| Ivermectin, Pyrantel | Convulsion | 666 |
| Grapiprant | Lethargy (see also Central nervous system depression in 'Neurological') | 659 |
| Prednisone | Death by euthanasia | 656 |
| Firocoxib | Elevated serum alkaline phosphatase (SAP) | 655 |
| Pyrantel Pamoate | Anorexia | 654 |
| Firocoxib | Death | 651 |
| Lotilaner | Lack of efficacy (bacteria) - Borrelia | 647 |
| Pyrantel Pamoate | Lack of efficacy (endoparasite) - heartworm | 642 |
| Pyrantel Pamoate | Death | 640 |
| Firocoxib | Elevated creatinine | 637 |
| Pyrantel | Diarrhoea | 633 |
| Imidacloprid | Anorexia | 629 |
| Lotilaner | Lethargy (see also Central nervous system depression in 'Neurological') | 624 |
| Lotilaner | Seizure NOS | 619 |
| Milbemycin, Lufenuron | Lack of efficacy (endoparasite) - hookworm | 616 |
| Prednisone | Other abnormal test result NOS | 613 |
| Meloxicam | Death | 607 |
| Meloxicam | Lethargy (see also Central nervous system depression in 'Neurological') | 606 |
| Gabapentin | Elevated alanine aminotransferase (ALT) | 593 |
| Cyclosporine | Elevated serum alkaline phosphatase (SAP) | 590 |
| Cefovecin | Lethargy (see also Central nervous system depression in 'Neurological') | 590 |
| Meloxicam | Death by euthanasia | 588 |
| Lufenuron | Emesis | 578 |
| Milbemycin, Lufenuron | INEFFECTIVE, ASCARIDS NOS | 562 |
| Gabapentin | Decreased appetite | 560 |
| Cefovecin | Vomiting | 547 |
| Nitenpyram | Diarrhoea | 541 |
| Prednisone | Emesis | 529 |
| Prednisone | Weight loss | 520 |
| Grapiprant | Elevated alanine aminotransferase (ALT) | 506 |
| Pyrantel | Lethargy (see also Central nervous system depression in 'Neurological') | 492 |
| Nitenpyram | Pruritus | 486 |
| Fluralaner Spot-On Solution | Lack of efficacy (ectoparasite) - flea | 486 |
| Cyclosporine | Elevated alanine aminotransferase (ALT) | 479 |
| Grapiprant | Death by euthanasia | 476 |
| Enrofloxacin | Lethargy (see also Central nervous system depression in 'Neurological') | 474 |
| Milbemycin, Lufenuron | Pruritus | 473 |
| Lotilaner | Lack of efficacy (endoparasite) - heartworm | 470 |
| Grapiprant | Not eating | 465 |
| Cyclosporine | INEFFECTIVE, ATOPY CONTROL | 464 |
| Milbemycin, Lufenuron | Anorexia | 451 |
| Nitenpyram | Scratching | 449 |
| Grapiprant | Decreased appetite | 427 |
| Enrofloxacin | Anorexia | 413 |
| Pyrantel | Emesis (multiple) | 408 |
| Pyrantel | INEFFECTIVE, HOOKS | 392 |
| Enrofloxacin | Death by euthanasia | 382 |
| Cefovecin | Anorexia | 340 |
| Enrofloxacin | Death | 333 |
| Cefovecin | Death | 330 |
| Enrofloxacin | Other abnormal test result NOS | 329 |
| Enrofloxacin | Diarrhoea | 302 |
| Buprenorphine | Vomiting | 250 |
| Enrofloxacin | Ataxia | 246 |
| Cefovecin | Diarrhoea | 242 |
| Cefovecin | Death by euthanasia | 218 |
| Cefovecin | Seizure NOS | 197 |
| Cefovecin | Other abnormal test result NOS | 196 |
| Buprenorphine | Lethargy (see also Central nervous system depression in 'Neurological') | 191 |
| Buprenorphine | Diarrhoea | 166 |
| Buprenorphine | Death by euthanasia | 154 |
| Buprenorphine | Anorexia | 148 |
| Buprenorphine | Death | 139 |
| Buprenorphine | Not eating | 115 |
| Fluralaner Spot-On Solution | Lack of efficacy (ectoparasite) - tick NOS | 114 |
| Buprenorphine | Other abnormal test result NOS | 114 |
| Fluralaner Spot-On Solution | Emesis (multiple) | 67 |
| Fluralaner Spot-On Solution | Lethargy (see also Central nervous system depression in 'Neurological') | 65 |
| Fluralaner Spot-On Solution | Seizure NOS | 60 |
| Fluralaner Spot-On Solution | Vomiting | 43 |
| Fluralaner Spot-On Solution | Diarrhoea | 41 |
| Fluralaner Spot-On Solution | Drug administered at inappropriate site | 33 |
| Frunevetmab | Lethargy (see also Central nervous system depression in Neurological) | 2 |
| Frunevetmab | General illness | 2 |
| Frunevetmab | Prescribing error | 2 |
| Frunevetmab | Behavioural disorder NOS | 1 |
| Frunevetmab | Confusion | 1 |
| Frunevetmab | Anorexia | 1 |
| Frunevetmab | Death by euthanasia | 1 |
| Frunevetmab | Emesis | 1 |